Efficacy and safety of apheresis therapy in AQP4 antibody-positive NMOSD attack: A propensity score-matched cohort study
Journal: CNS Neuroscience & Therapeutics; May 24, 2024
Author(s): Yun Xu, Huabing Wang, Tian Song, Linlin Yin, Yajun Yao, Yuzhen Wei, Hengri Cong, Jiali Sun, Xinghu Zhang, De-Cai Tian
How safe and effective are plasma exchange and immunoadsorption for NMOSD attacks?
Plasma exchange and immunoadsorption (a blood-cleaning method that eliminates disease-causing antibodies) are commonly used to treat NMOSD attacks. This study assessed how effective these treatments were when given in combination with steroids (intravenous methylprednisolone) during NMOSD attacks as opposed to when steroids were given alone. The results showed that patients who received plasma exchange and immunoadsorption along with steroid treatment had better and more long-lasting improvement in their neurological symptoms over six months than those who received steroids alone. The combination therapy was also found to be safe and well tolerated.
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